First responders fanned out across Israel Sunday following fresh waves of Iranian missile strikes that left pockets of devastation in their wake -- as the Islamic republic hit back after a US attack on its nuclear sites.

In both Haifa and areas around Tel Aviv, the scenes were all too similar.

Rubble filled streets at impact sites as the facades of apartment buildings were eviscerated by the falling projectiles, as rescue teams picked through the debris looking for people.

Three areas of Israel including coastal hub Tel Aviv were hit Sunday morning during waves of Iranian missile attacks, with at least 23 people injured, according to rescue services and police.

Several buildings were heavily damaged in the Ramat Aviv area in Tel Aviv, with holes torn in the facades of apartment blocks.

"Houses here were hit very, very badly," Tel Aviv mayor Ron Huldai told reporters at the scene. "Fortunately, one of them was slated for demolition and reconstruction, so there were no residents inside.

The US military attacked three sites in Iran on Sunday -- Natanz, Isfahan and the mountain-buried Fordo, all key parts of Tehran's nuclear programme, which it maintains is purely for civilian purposes.

American planes launched a "very successful attack", US President Donald Trump said, claiming Iran's main nuclear enrichment facilities had been "completely and totally obliterated".

Trump has said Tehran must never get a nuclear weapon, and ally Israel has claimed its attacks on Iran have set back the country's nuclear weapons progress by several years.

For nearly a half-century the United States has squabbled with Iran's Islamic Republic but the conflict has largely been left in the shadows, with US policymakers believing, often reluctantly, that diplomacy was preferable.

With President Donald Trump's order of strikes on Iran's nuclear sites, the United States -- like Israel, which encouraged him -- has brought the conflict into the open, and the consequences may not be clear for some time to come.

More than four months since his release from Gaza, former hostage Keith Siegel bears the mental scars of 484 days of captivity in destroyed buildings and tunnels in the hands of Palestinian militant group Hamas.

The 66-year-old Israeli-American and his wife Aviva were among 251 hostages seized from residential communities along the Gaza border, army bases and a music festival on October 7, 2023.

President Donald Trump delivered brief remarks from the White House late Saturday after the US military carried out strikes on Iranian nuclear sites.

Here is what Trump said in full:

"A short time ago the US military carried out massive precision strikes on the three key nuclear facilities in the Iranian regime: Fordo, Natanz and Isfahan.

"Everybody heard those names for years as they built this horribly destructive enterprise.

Mahmoud Khalil, one of the most prominent leaders of US pro-Palestinian campus protests, pledged Saturday to keep campaigning after he was released from a federal detention center.

"Even if they would kill me, I would still speak for Palestine," Khalil said as he was greeted by cheering supporters at Newark airport, just outside New York City.

Khalil, a legal permanent resident in the United States who is married to a US citizen and has a US-born son, had been in custody since March facing potential deportation.

A privately run aid organisation brought in to distribute food rations in war-hit Gaza last month with US and Israeli backing said Saturday that people in the Palestinian territory "desperately need more aid".

The admission by the Gaza Humanitarian Foundation (GHF) that it has been unable to meet demand came after severe criticism from other aid groups and near-daily deadly shootings near distribution points.

Tens of thousands of pro-Palestinian protesters marched in European cities calling for an end to the war in Gaza, hours before President Donald Trump said the US military had attacked three Iranian nuclear sites Sunday.

In London, AFP journalists saw tens of thousands of protesters, who waved Palestinian flags as they marched through the British capital clad in keffiyeh scarves.

In Berlin, more than 10,000 people gathered in the centre of the city in support of Gaza, according to police figures.

Thousands marched on Saturday outside a French trade fair, calling for an end to war profiteering and Israel's offensive in Gaza in the latest demonstration to hit the event.

The long-planned protest at the Paris Air Show outside the French capital also comes as Israel's war with Iran drags on into a ninth day, with Tehran threatening to hit back in force at Israel's offensive against its arch-rival.