By Jasper Ward

WASHINGTON, Feb 28 (Reuters) - U.S. President Donald Trump said on Saturday that the United States had begun "major combat operations" in Iran, warning that there may be U.S. casualties.

The strikes, which Trump said were aimed at destroying Iranian missiles and annihilating its navy, follow repeated U.S.-Israeli warnings that they would strike Iran again if it pressed ahead with its nuclear and ballistic missile programs.

"I do not make this statement lightly. The Iranian regime seeks to kill," Trump said in a video shared on Truth Social.

US President Donald Trump announced a major attack against Iran on Saturday, vowing to "annihilate" the country's navy and missile sites, and urging Iranians to overthrow their government.

In a video address after the United States and Israel started bombing Iran, Trump made clear the goal was destruction of the Islamic republic's military and toppling of the authorities in power since the 1979 revolution.

By Phil Stewart, Parisa Hafezi and Menna AlaaElDin

WASHINGTON, DUBAI, CAIRO, Feb 28 - Israel launched a pre-emptive attack against Iran on Saturday, and a United States attack is underway, plunging the Middle East into a renewed military confrontation and further dimming hopes for a diplomatic solution to Tehran's nuclear dispute with the West.

Feb 28 (Reuters) - The Israeli operation against Iran on Saturday was coordinated with the U.S., an Israeli defence official told Reuters.

The operation was planned for months and the launch date was decided weeks ago, the official added.

(Reporting by Rami Ayyub; Editing by Kate Mayberry)

Feb 28 (Reuters) - Israel said it launched a pre-emptive attack against Iran on Saturday, pushing the Middle East into a renewed military confrontation and further dimming hopes for a diplomatic solution to Tehran's long-running nuclear dispute with the West.

The New York Times, citing a U.S. official, reported that U.S. strikes on Iran were underway. A source told Reuters that Iran's supreme leader, Ayatollah Ali Khamenei, was not in Tehran and had been transferred to a secure location.

KABUL, Feb 28 (Reuters) - Fighting between Pakistan and Afghanistan's Taliban military entered its third day on Saturday, following overnight clashes as the international community expressed increasing concern about the conflict and called for urgent talks.

Pakistan's strikes on Friday hit Taliban military installations and posts, including in Kabul and Kandahar, in one of the deepest Pakistani incursions into its western neighbour in years, officials said.

By Kanishka Singh

WASHINGTON, Feb 27 (Reuters) - The United States said on Friday it supported Pakistan's "right to defenditself" against attacks from Afghanistan's Taliban rulers after Islamabad said earlier in the day that the neighboring countries were in "open war."

Afghanistan's Taliban rulers had said on Friday they were willing to negotiate after Pakistan bombed their forces in major cities.

Veteran Hollywood star Susan Sarandon on Friday praised the Spanish government's support for Gaza, saying it was "on the right side of history".

"I think Spain is doing an incredible job," Sarandon, her voice trembling with emotion, told reporters in Barcelona.

She lauded Spanish Prime Minister Pedro Sanchez and actors such as Oscar-winner Javier Bardem for taking a strong public stand in support of Palestine.

"When you turn on the TV and see how strong Spain is and how clear you are morally on these issues, it makes you feel less alone," Sarandon said.

ROME, Feb 27 (Reuters) - Italy's foreign ministry on Friday urged its citizens to leave Iran and advised extreme caution across the Middle East, citing persistently unstable security conditions.

"Italians in (Iran) for tourism or whose presence is not strictly necessary are urged to depart," the ministry said in a statement, adding that travel to Iraq and Lebanon was also strongly discouraged.

It advised Italian nationals in Israel to exercise maximum caution and remain vigilant.

WASHINGTON, Feb 27 (Reuters) - U.S. President Donald Trump said he was not happy with Iran but more talks were expected on Friday on Tehran's nuclear program.

Speaking to reporters before a trip to Texas, Trump said he wants to make a deal with Iran but reiterated that Tehran cannot have a nuclear weapon.

Talks over Tehran's nuclear program continued this week amid a massive U.S. military buildup in the region. Trump said he does not want to use military force in Iran but sometimes you have to.