By Enas Alashray and Phil Stewart

CAIRO/WASHINGTON, April 5 (Reuters) - U.S. President Donald Trump and Israel on Saturday stepped up pressure on Iran to open the strategic Strait of Hormuz or face attacks on its energy infrastructure, while Iranian and U.S. forces searched for a missing U.S. crew member from one of two downed warplanes.

Trump, who has sent mixed messages since the conflict began with a joint U.S.-Israeli bombardment of Iran on February 28, told Tehran that his latest deadline for a deal to end the war was fast approaching.

By Joshua McElwee

VATICAN CITY, April 4 (Reuters) - Pope Leo led the world's Catholics into Easter at a Saturday night vigil Mass in St. Peter's Basilica and urged people not to feel numbed by the scope of the conflicts raging across the world but to work for peace.

Leo, who has emerged as an outspoken critic of the Iran war, said that mistrust and fear have been allowed to "sever the bonds between us through war, injustice and the isolation of peoples and nations."

PRAGUE, April 4 (Reuters) - Authorities detained two more people in connection with the arson attack on a Czech optics and drone factory last month, Czech police and a public prosecutor's office said on Saturday.

A previously unknown pro-Palestinian activist group has claimed responsibility for the March 20 fire at an industrial complex in Pardubice, about 120 km (75 miles) east of Prague.

Czech authorities have previously announced five detentions, including of an Egyptian and a U.S. citizen, since the fire that targeted a building used by Czech defence group LPP Holding.

Bushehr nuclear power plant, Iran's only operational civilian nuclear facility, was built by Russia and officially handed over in September 2013, after decades of twists, turns and delays linked to Iran's turbulent history.

The facility, located in the south of the country and equipped with a 1,000-megawatt reactor, was hit Saturday by a US-Israeli airstrike, killing a security guard, Iranian state media reported.

The Middle East war "presents a serious risk to Africa", the African Union and the African Development Bank (AfDB) said in a report seen by AFP Saturday.

The conflict threatens to increase the cost of living and curtail growth on the continent, the report warned.

The Middle East accounts for 15.8 percent of Africa's imports and 10.9 percent of its exports, the report noted.

MOSCOW, April 4 (Reuters) - Russia's state nuclear company Rosatom evacuated a further 198 of its staff from Iran's Bushehr nuclear power plant on Saturday, Russian news agencies reported.

Rosatom has been evacuating staff from the plant since the Iran war broke out at the end of February.

Saturday's evacuations had been planned before the International Atomic Energy Agency said in a post on X on Saturday that one of the plant’s physical protection staff was killed by a projectile fragment and that a building on site was affected by shockwaves and fragments.

WARSAW, April 4 (Reuters) - The European Union should end sanctions on Russian oil and gas imports, take steps to restore Druzhba oil flows and end the war in Ukraine to fight against the energy crisis stemming from the war in Iran, Slovak Prime Minister Robert Fico said on Saturday.

KYIV, April 4 (Reuters) - Ukrainian President Volodymyr Zelenskiy has arrived in Istanbul for talks with Turkey's President Tayyip Erdogan, Zelenskiy's spokesman said on Saturday.

The spokesman also told reporters that Zelenskiy would meet Patriarch Bartholomew, the most senior cleric in the Orthodox Church.

(Reporting by Max Hunder;Editing by Alison Williams)

By Nandita Bose, Jana Winter, Gram Slattery and Andrea Shalal

WASHINGTON, April 4 (Reuters) - U.S. President Donald Trump is considering a broader cabinet shake-up in the wake of Attorney General Pam Bondi's removal this week, as he grows increasingly frustrated with the political fallout from the war with Iran, five people familiar with internal White House discussions said.

The Israeli military said on Saturday it would strike an area near the main crossing between Syria and Lebanon, urging residents to evacuate immediately as it continued its attacks across Lebanon.

Israel has carried out strikes across Lebanon and launched a ground invasion in the south since March 2, when Hezbollah entered the war in the Middle East on the side of its backer Iran.