Mazal Mualem started her journalistic career during her military service in Israel, where she was assigned to the weekly army newspaper Bamachane. After her studies, she worked for the country's second-largest Hebrew-language daily, Maariv. In 1998, she joined the English-language daily Haaretz, covering local governance, and later, she was appointed chief political analyst for that paper. After 12 years with Haaretz, she returned to Maariv as their chief political analyst.
Parallel to her writing activities, Mazal Mualem presented a weekly TV show on social issues.
Mazal Mualem holds a master's degree from the Tel Aviv University in security/political science. She lives with her daughter in Tel Aviv.